Vitamin D and Omega-3 Slow Aging

Previously in DO-HEALTH (including all 2,157 participants), we reported that omega-3 alone reduced the rate of infections by 13% (ref. 22) and the rate of falls by 10% (ref. 23), and all three interventions combined showed a significant additive benefit on reducing prefrailty by 39% (ref. 24) and incident invasive cancer by 61% (ref. 25) over a 3-year follow-up. The aim of the DNAm analysis in DO-HEALTH Bio-Age was to assess the effects of the interventions at the molecular level. Three of th...

 How Steroids Produce Rage in Users

I pride myself on never losing my cool I've never screamed at anyone I've never gotten physical with anyone but the ideas in my head that tell me to do things tell me to do unspeakable things like what they're unspeakable I'd have to speak them you really want to know Mum I'm also [ __ ] weird so just remember that no we bit most people uhprobably don't have this severity but I'll read a comment on social media directed at me I guess about me um and it's from like you know nameless faceless ...

 Exercise Prevents Spending Calories on Fat Storage and Ot...

The reason for that is because exercise causes stress and that stress turns on a whole raft of beneficial effects. And there are really two kinds of this stress. Now, the first kind is energetic stress. Like I went for a run this morning, I spent probably about 500 calories running and I can only do so many things with the calories my body has. And if I spend 500 extra calories exercising, that means I'm not gonna spend 500 calories on other activities that my bother body might engage in. An...

 Exercise Creates Structural Stress

Now, the other kind of stress Structural stress from activity that physical activity cause is structural stress. Now, when I was running this morning, for example, my mitochondria were generating all kinds of ATP to fuel my body, but my mitochondria were also spewing out all kinds of reactive oxygen species, which cause widespread damage throughout my body. I was getting mutations in my DNA, those that damage is causing my telomeres at the end of my chromosomes to shorten its damaging cells. ...

 Why Humans Evolved to be Active

Humans of all to be much more physically active than our ape ancestors. Typical chimpanzee walks maybe two to three kilometers a day, and they take maybe what, three, 4,000 steps a day. A typical hunter-gatherer takes about 15 to 20,000 steps a day. Per kilo hunter-gatherers spend about twice as much energy per kilo on being physically active per day than our ape cousins. And importantly, that physical activity occurs as we age, right? So Americans are pretty inactive, as we all know. A typ...

 Digestive Enzymes Leaking into the Body May Increase Aging

In young rats, the researchers found low levels of the protein-breaking enzyme trypsin, although the tiny folds (villi) of the small intestine and the lungs contained more of this molecule. However, trypsin levels were much higher in old animals. “High densities are on sections of the intestine, liver, and lung, organs that are in the pathway of digestive enzymes leaking from the small intestine,” the paper says. Elevated levels of other digestive enzymes (elastase, lipase, and amylase) ...

 Marketplace of Ideas in COVID Responses

One way of gauging the current diversity of cultures is to consider the range of responses countries made to the COVID-19 pandemic.120 There was, of course, some diversity, from the ultrastrict lockdowns in China to the more moderate response in Sweden. But the range of responses was far more limited than it could have been. For example, both the Moderna and the Pfizer-BioNTech vaccines were designed by mid-January 2020 over the course of a few days.121 Not a single country allowed human chal...

 A 1700s Rich Man in Britain

The best that we have seen so far is a poor guide to what is possible. To get some inkling of this, consider the life of a rich man in Britain in 1700—a man with access to the best food, health care, and luxuries available at the time. For all his advantages, such a man could easily die of smallpox, syphilis, or typhus. If he needed surgery or had a toothache, the treatment would be agonising and carry a significant risk of infection. If he lived in London, the air he breathed would be seve...

 1979 Dystopian Vision That Came True

I HAVE THIS recurring nightmare. Jonas Salk has just announced his cure for polio. A bill is introduced in Congress to require mandatory inoculation of school children under HEW direction. Opposition then appears. Ronald Reagan urges "free choice by parents rather than compulsion by government." Mobil runs advertisements with the headline, "From gas tanks to bloodstreams. Where will government go next?" An associate professor of economics does a study for the American Enterprise Institute dem...

 Seeing Organizations as Biological Systems

There’s a continuing struggle between complexity and robustness in both evolution and human design. A kind of survival imperative, whether in biology, engineering, or business requires that simple, fragile systems become more robust. But the mechanisms to increase robustness will in turn make the system considerably more complex. Furthermore, that additional complexity brings with it its own unanticipated failure modes, which are corrected over time with additional robust mechanisms, which ...